Journal
NANOMEDICINE
Volume 13, Issue 4, Pages 391-405Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0297
Keywords
bioactivity; bleeding; carbon dots; cell counting kit; coagulation parameters; cytotoxicity; hemostasis; mechanism; Phellodendri Cortex Carbonisatus; platelets
Funding
- National Natural Science Foundation [81573573, 81503344, 81473338]
- Young teacher special projects of Beijing University of Chinese Medicine [2015-JYB-JSMS014]
- Classical Prescription Basic Research Team of Beijing University of Chinese Medicine
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Aim: To explore the hemostatic effect of Phellodendri Cortex-derived carbon dots. Materials & methods: Transmission electron microscopy, high-resolution transmission electron microscopy, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, fluorescence spectroscopy, x-ray photoelectron spectroscopy and a cell counting kit-8 assay were studied. Hemostatic effect of Phellodendri Cortex Carbonisatus-carbon dots (PCC-CDs) was studied in mouse bleeding models. To explore their related hemostatic mechanism, coagulation parameters and platelets were measured. Results: The PCC-CDs ranged in diameter from 1.2 to 4.8 nm and had a quantum yield of 9.62%. They exhibited no toxicity up to concentrations of 1000 mu g/ml. After administration, mice had a significantly shortened bleeding time and coagulation parameters and platelets significantly increased. Conclusion: These results showed the definite hemostatic effect of PCC-CDs.
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