Journal
NANOMEDICINE
Volume 13, Issue 3, Pages 269-282Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0277
Keywords
absorption mechanism; oral bioavailability; paeonol nanoemulsion
Funding
- National Natural Science Fund of China [81473386, 81773937, 81001703]
- Excellent Researcher Award Program of Anhui Province [gxyqZD2016135]
- Science Program of Anhui province [KJ2015A061]
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The aim of this work was to optimize a nanoemulsion formulation and explain its absorption mechanism in improving the oral bioavailability of paeonol. Method: The bioavailability of paeonol was compared between paeonol nanoemulsion group and paeonol suspension group. The in situ single-pass intestine perfusion method, in vitro everted gut sacs method, Western blot analysis and Caco-2 cell transport studies were used to investigate the absorption mechanism of nanoemulsion. Results: Nanoemulsion was proved to enhance the bioavailability of paeonol. P-glycoprotein (P-gp) mediated efflux might be the main reason affecting the oral absorption of paeonol. The prepared nanoemulsion prevented the P-gp-mediated efflux and enhanced the bioavailability of paeonol. Conclusion: The overall results revealed that nanoemulsion was an effective vehicle to improve the oral bioavailability of paeonol which resulted from the prevention of P-gp efflux probably.
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