Journal
NANO TODAY
Volume 18, Issue -, Pages 65-85Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2017.12.007
Keywords
Nanomedicine; Dual-ligand; Tumor-targeted delivery; Tumor therapy; Receptor-mediated endocytosis; Cell-penetrating peptides; Targeting efficacy
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Funding
- National Natural Science Foundation of China [NSFC 51633005]
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Based on the overexpression of specific receptors on tumor cells, active targeting nanomedicines have been developed with the ability to efficiently deliver imaging agents in the tumor area or anticancer drugs into tumor cells via receptor-mediated endocytosis. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumor microenvironment. In recent years, dual-ligand nanomedicines have attracted a lot of interest, because these nanomedicines endowed with versatile functions, have the potential to improve the efficacy of tumor-targeted delivery. In this review, an overview of various dual-ligand nanomedicines for tumor targeted therapy will be presented, the role of cell penetrating peptides in combination with targeting ligands will be discussed and factors that affect the targeting efficacy of dual-ligand nanomedicines will be evaluated. (C) 2017 Elsevier Ltd. All rights reserved.
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