Journal
NANO TODAY
Volume 21, Issue -, Pages 14-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2018.03.001
Keywords
Biomolecular corona; Principal component analysis; Early disease detection; Personalized medicine; Nanomedicine
Ask authors/readers for more resources
Today, early disease detection (EDD) is a matter of more importance than ever in medicine. Upon interaction with human plasma, nanoparticles are covered by proteins leading to formation of a biomolecular corona (BC). As the protein patterns of patients with conditions differ from those of healthy subjects, current research into technologies based on the exploitation of personalized BC patterns could be a turning point for early disease detection. Here, we present a framework based on principal component analysis of large personalized BC datasets. We comment on how principal component analysis of personalized BC data is a fundamental step towards turning the output of basic research into fast, safe and inexpensive technologies with superior prediction ability than current methods. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available