Journal
NANO RESEARCH
Volume 11, Issue 10, Pages 5258-5280Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-018-2135-4
Keywords
optical imaging; reactive oxygen and nitrogen species; fluorescent; upconversion luminescence; chemiluminescence; photoacoustic imaging
Categories
Funding
- Nanyang Technological University [NTUSUG: M4081627.120]
- Singapore Ministry of Education [RG133/15 M4011559, 2015-T1-002-091, MOE2016-T2-1-098]
Ask authors/readers for more resources
Reactive oxygen and nitrogen species (RONS) play important roles in cell signal transduction. However, overproduction of RONS is associated with a series of pathological processes and may disrupt cellular homeostasis, causing oxidative and nitrosative stress. Accurate methods to selectively and specifically monitor RONS in living systems are required to further elucidate the biological functions of these species. Optical imaging possesses high sensitivity, high spatiotemporal resolution, and real-time imaging capability. These qualities are advantageous for the detection of RONS in living systems. This review summarizes the development of optical nanoprobes with near-infrared (NIR) fluorescent, upconversion luminescent, chemiluminescent, or photoacoustic signals for molecular imaging of RONS in living systems. In this review, we discuss the design principles and advantages of RONS-responsive activatable nanoprobes, as well as applications of these optical imaging modalities in different disease models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available