Journal
NANO RESEARCH
Volume 11, Issue 4, Pages 2285-2294Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-017-1850-6
Keywords
fluorescent silicon nanoparticles; multi-function; red blood cells; drug delivery system
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Funding
- National Basic Research Program of China [2013CB934400]
- National Natural Science Foundation of China [61361160412, 31400860]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 111 Project
- Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC)
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Based on the unique advantages of fluorescent silicon nanoparticles (SiNPs), long circulation red blood cells (RBCs), and anti-cancer drug molecules (i.e., doxorubicin (DOX)), we developed multifunctional DOX-loaded SiNPs impregnated into RBCs. Importantly, the resulting drug delivery systems (DDSs) simultaneously exhibited bright fluorescence coupled with robust photostability (i.e., similar to 24% loss of fluorescent intensity after 25 min continuous laser irradiation) and significantly lengthened blood residency (i.e., t(1/2) = 7.31 +/- 0.96 h, 3.9-fold longer than pure DOX-loaded SiNPs). Therefore, this novel DDS featuring multi-functionalities shows high potential for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in a synchronous manner.
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