Journal
CLINICAL AND BIOMEDICAL SPECTROSCOPY AND IMAGING III
Volume 8798, Issue -, Pages -Publisher
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2033185
Keywords
Molecular beacon; PMMA nanoparticles; intracellular sensing; mRNA; survivin
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We describe here the conjugation of polymethylmethacrylate nanoparticles to particular oligonucleotide switches, termed molecular beacons (MBs), as potential intracellular nanosensors. Survivin mRNA targeting MBs have been used with Atto647N and Blackberry 650 as fluorophore/quencher pair. The nanosensors have been characterized in vitro by investigating the analytical performances of the chosen molecular beacon and its functionalities after conjugation to the nanoparticles.
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