Journal
WORLD JOURNAL OF HEPATOLOGY
Volume 5, Issue 9, Pages 479-486Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4254/wjh.v5.i9.479
Keywords
Hepatitis C virus; MicroRNA; Liver disease; Interferon signaling; Circulatory microRNA
Categories
Funding
- National Institutes of Health [DK081817]
- SLU Liver Center Seed Grant
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Hepatitis C virus (HCV) is a global health problem with an estimated 170-200 million peoples (approximately 3% of world population) are chronically infected worldwide and new infections are predicted to be on rise in coming years. HCV infection remains categorized as a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. There has been considerable improvement in our understanding of virus life cycle since, the discovery of HCV two-decades ago. MicroRNAs (miRNAs) are important players in establishment of HCV infection and their propagation in infected hepatocytes. They target crucial host cellular factors needed for productive HCV replication and augmented cell growth. Very first anti-miRNA oligonucleotides, miravirsen has been tested in clinical trial and shown promising results as therapeutic agent in treatment against chronic HCV infection. Deregulated expression of miRNAs has been linked to the pathogenesis associated with HCV infection by controlling signaling pathways such as, proliferation, apoptosis and migration. Circulating miRNAs emerging as growing field in identification of biomarkers in disease progression and their potential as a means of communication between cells inside the liver is an exciting area of research in future. This review focuses on recent studies enforcing the contribution of miRNAs in HCV life cycle and coordinated regulation in HCV mediated liver disease progression. (C) 2013 Baishideng. All rights reserved.
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