Journal
HETEROCYCLIC COMMUNICATIONS
Volume 21, Issue 4, Pages 215-218Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hc-2015-0055
Keywords
4-bromo-3,6-dichloropyridazine; 4-bromo-1,2-dihydropyridazine-3,6-dione; 3-bromomaleic anhydride; 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines; heterocyclization; 15-lipoxygenase inhibitor
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Funding
- Ferdowsi University of Mashhad
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New 10H-benzo[b] pyridazino[3,4-e][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.
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