Journal
MOVEMENT DISORDERS
Volume 33, Issue 9, Pages 1488-1492Publisher
WILEY
DOI: 10.1002/mds.27365
Keywords
progressive supranuclear palsy; Parkinson's disease; neuromelanin; midbrain; volumetry
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Funding
- Strategic Research Foundation [25461290, 24390224]
- Brain Mapping by Integrated Neurotechnologies for Disease Studies Project
- Japan Science and Technology Agency
- Japan Agency for Medical Research and Development for Promoting Clinical trials for development of New Drugs and Medical Devices
- Research Committee of CNS Degenerative Disease, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health, Labour and Welfare Sciences Research Grants, the Ministry of Health, Labour and Welfare, Japan
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Background Nigral degeneration patterns differ between PSP and PD. However, the relationship between nigral degeneration and midbrain atrophy in PSP remains unclear. Objective We analyzed differences and relationships between nigral degeneration and midbrain atrophy in PSP and PD. Methods Neuromelanin-sensitive MRI and midbrain volumetry were performed in 11 PSP patients, 24 PD patients, and 10 controls to measure the neuromelanin-sensitive SNpc area and midbrain volume. Results The neuromelanin-sensitive SNpc area and midbrain volume were significantly smaller in PSP patients compared with PD patients and controls. Motor deficits were inversely correlated with neuromelanin-sensitive SNpc area in PD, but not PSP patients. There was no significant correlation between neuromelanin-sensitive SNpc area and midbrain volume in either disease group. Midbrain volumetry discriminated PSP from PD. Diagnostic accuracy was improved when neuromelanin-sensitive MRI analysis was added. Conclusions Neuromelanin-sensitive MRI and midbrain volumetry may reflect the clinical and pathological characteristics of PSP and PD. Combining neuromelanin-sensitive MRI and midbrain volumetry may be useful for differentiating PSP from PD. (C) 2018 International Parkinson and Movement Disorder Society
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