Journal
HETEROCYCLES
Volume 91, Issue 3, Pages 479-504Publisher
Japan Inst Heterocyclic Chemistry
DOI: 10.3987/REV-14-816
Keywords
Substituted Pyridine; Lithium Reagent; Directed Lithiation; Directing Metalating Group; Electrophile
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Funding
- Deanship of Scientific Research at King Saud University [RGP-VPP-239]
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Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding.
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