4.2 Article

SITE-SELECTIVE INTRODUCTION OF AN ENAMIDO GROUP AT THE C(3)-POSITION OF INDOLES

Journal

HETEROCYCLES
Volume 91, Issue 8, Pages 1579-1584

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-15-13261

Keywords

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Funding

  1. MEXT
  2. ACT-C program of the JST
  3. JSPS
  4. Grants-in-Aid for Scientific Research [14J05174, 15H05756] Funding Source: KAKEN

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An enamido group is introduced site-selectively at the C(3)-position of indoles by the rhodium(II)-catalyzed reaction with N-sulfonyl-1,2,3-triazoles. Formally, an alpha-imino rhodium carbene complex is inserted into the C(3)-H bond of an indole.

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