Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 11, Pages 6282-6292Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b00529
Keywords
magnetic nanoparticles; silk protein; magnetic scaffold; magnetic gradient; magnetic field; hyperthermia; biomaterials; tissue engineering
Funding
- EC-FP7 project MAGISTER [NMP3-LA-2008-214685]
- NIH [EB002520]
- AFOSR
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Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 degrees C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.
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