Journal
WORLD JOURNAL OF ORTHOPEDICS
Volume 4, Issue 4, Pages 186-197Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.5312/wjo.v4.i4.186
Keywords
Receptor activator of nuclear factor kappa B ligand; Osteoprotegerin; Receptor activator of nuclear factor kappa B; Osteoclasts; Bone biology
Categories
Funding
- National Health and Medical Research Council (Australia)
- Victorian Government OIS Program
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After it was suggested 30 years ago that the osteoblast lineage controlled the formation of osteoclasts, methods were developed that established this to be the case, but the molecular controls were elusive. Over more than a decade much evidence was obtained for signaling mechanisms that regulated the production of a membrane - bound regulator of osteoclastogenesis, in the course of which intercellular communication in bone was revealed in its complexity. The discovery of regulation by tumor necrosis factor ligand and receptor families was made in the last few years of the twentieth century, leading since then to a new physiology of bone, and to exciting drug development. (C) 2013 Baishideng. All rights reserved.
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