Journal
BIOMEDICAL REPORTS
Volume 1, Issue 6, Pages 833-836Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2013.169
Keywords
proinflammatory genes; keloid formation; skin lesion
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Funding
- National Natural Science Foundation of China [81260291]
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It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post-traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the continuous upregulation of proinflammatory gene expression in keloid lesions. This hypothesis may explain the inflammatory response, invasive growth and recurrence following resection of keloids, as well as the selective localization of keloids in specific parts of a patient's body and the differences in localization among different patients.
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