Journal
MOLECULES
Volume 23, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules23061402
Keywords
inhibitory activity; catalysis; cyclization; olivacine; palladium; pyrido[4,3-b]carbazoles
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The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of Mycobacterium tuberculosis, 9-methoxyolivacine showed the most significant inhibitory activity against Mycobacterium tuberculosis, with an MIC90 value of 1.5 mu M.
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