Spirostane-Type Saponins Obtained from Yucca schidigera

It is well known that spirostane-type saponins show various bioactivities. In our on-going program of screening these kinds of constituents from natural products, Yucca schidigera was found to be rich in them, and nine new spirostanol saponins, Yucca spirostanosides A(1) (1), A(2) (2), B-1 (3), B-2 (4), B-3 (5), C-1 (6), C-2 (7), C-3 (8), and D-1 (9), together with five known ones (10-14) were isolated from the plant. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and MS spectra, and comparing with published data.