Journal
MOLECULES
Volume 23, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/molecules23010087
Keywords
Acanthopanax gracilistylus; Araliaceae; lupane-triterpene; acangraciligenin S; acangraciliside S
Funding
- Natural Science Foundation of Hunan Province, China [11JJ2042]
- Key Projects of Changsha City Science and Technology Bureau [k1403122-31]
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The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3,11-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1,3-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1,3-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[-l-rhamnopyranosyl-(14)--d-glucopyranosyl-(16)--d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production.
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