Journal
MOLECULES
Volume 23, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules23040959
Keywords
protein-protein interactions; peptidomimetics; proteomimetics; macrocycles; stapled peptides
Funding
- EPSRC [EP/P020291/1]
- EPSRC [EP/P020291/1] Funding Source: UKRI
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Protein-protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many protein-protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain alpha-helices through stapling using both one-and two-component techniques.
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