Journal
MOLECULES
Volume 23, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules23040826
Keywords
chemotherapy; nanoparticles; combination therapy; theranostic nanoparticles; cancer
Funding
- National Nature Science Foundation of China [81570655, 81770728, 51703178]
- China Postdoctoral Science Foundation [2015M580855]
- Shaanxi Postdoctoral Science Foundation [2016BSHEDZZ100]
- Fundamental Research Funds for the Central Universities [xjj2016084]
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Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.
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