4.5 Article

Resilience to childhood maltreatment is associated with increased resting-state functional connectivity of the salience network with the lingual gyrus

Journal

CHILD ABUSE & NEGLECT
Volume 37, Issue 11, Pages 1021-1029

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chiabu.2013.07.008

Keywords

Resilience; Childhood maltreatment; Resting-state functional connectivity; Lingual gyrus

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The experience of childhood maltreatment is related to an increased risk of developing a variety of psychiatric disorders, as well as a change in the structure of the brain. However, not much is known about the neurobiological basis of resilience to childhood maltreatment. This study aims to identify resting-state functional connectivity (RSFC) patterns specific for resilience to childhood maltreatment, focusing on the default mode and salience network and networks seeded from the amygdala and left dorsomedial prefrontal cortex. Resting-state functional MRI scans were obtained in 33 individuals. Seeds in the bilateral amygdala, the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex and the left dorsomedial prefrontal cortex were defined and used to examine whether resilient individuals differed from vulnerable individuals and healthy controls in RSFC with other brain regions. Within the salience network, the resilient group was associated with increased RSFC between the left dACC and a region containing the bilateral lingual gyrus and the occipital fusiform gyrus compared to both the vulnerable group and the healthy controls. In this study, we found RSFC patterns specific for resilient individuals. Regions that are implicated are related on a functional level to declarative memory and the processing of emotional stimuli. (C) 2013 Elsevier Ltd. All rights reserved.

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