Y-86/90-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model

Angiogenesis is widely recognized as one of the hallmarks of cancer. Therefore, imaging and therapeutic agents targeted to angiogenic vessels may be widely applicable in many types of cancer. To this end, the theranostic isotope pair, Y-86 and Y-90, were used to create a pair of agents for targeted imaging and therapy of neovasculature in murine breast cancer models using a chimeric anti-CD105 antibody, TRC105. Serial positron emission tomography imaging with Y-86-DTPA-TRC105 demonstrated high uptake in 4T1 tumors, peaking at 9.6 +/- 0.3%ID/g, verified through ex vivo studies. Additionally, promising results were obtained in therapeutic studies with Y-90-DTPA-TRC105, wherein significantly (p < 0.05) decreased tumor volumes were observed for the targeted treatment group over all control groups near the end of the study. Dosimetric extrapolation and tissue histological analysis corroborated trends found in vivo. Overall, this study demonstrated the potential of the pair Y-86/90 for theranostics, enabling personalized treatments for cancer.