Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 62, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201700856
Keywords
insulin resistance; liver; metabolic syndrome; obesity; skeletal muscles
Categories
Funding
- National Center for Complementary and Integrative Health
- Office of Dietary Supplements of the National Institutes of Health [P50AT002776]
- Botanical and Dietary Supplement Research Center of Pennington Biomedical Research Center
- Department of Plant Biology and Pathology in the School of Environmental and Biological Sciences (SEBS) of Rutgers University
- Pennington Biomedical Research Center COBRE [NIH8 1P30GM118430-01]
- National Institute of Health
- Pennington Biomedical Research Center NORC Center [P30 DK072476]
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Scope: The primary disorder underlying metabolic syndrome is insulin resistance due to excess body weight and abdominal visceral fat accumulation. In this study, it is asked if dietary intake of an ethanolic extract from Russian tarragon (Artemisia dracunculus L., termed PMI5011), shown to improve glucose utilization by enhancing insulin signaling in skeletal muscle, could prevent obesity-induced insulin resistance, skeletal muscle metabolic inflexibility, and ectopic lipid accumulation in the skeletal muscle and liver. Methods and results: Male wild-type mice are fed a high-fat diet alone or supplemented with PMI5011 (1% w/w) over 3 months. Dietary intake of PMI5011 improved fatty acid oxidation and metabolic flexibility in the skeletal muscle, reduced insulin levels, and enhanced insulin signaling in the skeletal muscle and liver independent of robust changes in expression of factors that control fatty acid oxidation. This corresponds with significantly reduced lipid accumulation in the skeletal muscle and liver, although body weight gain is comparable to a high-fat diet alone. Conclusion: Previous studies showed that PMI5011 enhances insulin sensitivity in the setting of established obesity-induced insulin resistance. The current study demonstrates that dietary intake of PMI5011 prevents high-fat diet-induced insulin resistance, metabolic dysfunction, and ectopic lipid accumulation in the skeletal muscle and liver without reducing body weight.
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