Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 62, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201700485
Keywords
fuzhuan brick tea; gut microbiota; high-fat diet; kudingcha; obesity
Categories
Funding
- National Natural Science Foundation of China [31171666]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX17_0632]
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ScopeKudingcha (KDC) from Ilex kudingcha and Fuzhuan brick tea (FBT) are popular beverages in China, and their preventive and therapeutic roles in metabolic disorders have been reported. However, the relationship between the gut microbiota modulatory effects of KDC and FBT and prevention of obesity is still not clearly understood. Methods and resultsKDC and FBT are tested individually for their capacities to prevent obesity and modulate the gut microbiota in high-fat diet (HFD) fed C57BL/6J mice. The results show that both KDC and FBT supplementation could modulate oxidative injury, inflammation, lipid metabolism, and reduce HFD induced obesity significantly. Both KDC and FBT could enhance the diversity of gut microbiota. KDC could reduce the relative abundance of Erysipelotrichaceae, while FBT could reduce the ratio of Firmicutes to Bacteroidetes and enhance the relative abundance of Bifidobacteriaceae. ConclusionThese findings suggest that KDC and FBT could attenuate features of the metabolic syndrome in HFD-fed mice, which might be due to the modulation of gut microbiota by KDC and FBT.
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