Journal
MOLECULAR NEUROBIOLOGY
Volume 56, Issue 1, Pages 763-767Publisher
SPRINGER
DOI: 10.1007/s12035-018-1166-x
Keywords
Interleukin 10; Interleukin 6; Functional status; Cognitive deficits
Categories
Funding
- National Council for Scientific and Technological Development (CNPq)
- NENASC project (PRONEX program CNPq/FAPESC)
- PPSUS-FAPESC
- Universidade do Extremo Sul Catarinense
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Persistent inflammation in intensive care unit (ICU) survivors is associated with higher long-term mortality and poorer mobility. However, it is unknown if inflammatory markers are associated with other dysfunctions observed in survivors of critical illness. Thus, it was investigated if plasma levels of interleukin (IL)-6 and IL-10 at hospital discharge were associated with long-term functional and cognitive performance after ICU discharge. Adult patients admitted for >48h to a 20-bed mixed ICU in a University Hospital had blood collected within 48h before hospital discharge to measure IL-6 and IL-10 levels. After a median time of 48months, cognitive status was determined by the Mini-Mental State Examination (MMSE), and functional status was determined by the Barthel Index. Patients at the higher 25th percentile of both IL-6 and IL-10 had a worse long-term cognitive performance, but not worse functional status, even when adjusted for confounders after long-term follow-up. In conclusion, elevated circulating IL-6 and IL-10 concentrations at hospital discharge were associated with long-term cognitive dysfunction in ICU survivors.
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