Journal
MOLECULAR MEDICINE REPORTS
Volume 17, Issue 4, Pages 5037-5042Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2018.8533
Keywords
colorectal cancer; COL1A1; WNT; PCP pathway; metastasis; bioinformatics analysis
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Funding
- Xinxiang Medical College [XYBSKYZZ201632, 2014ZD109]
- Higher Education Institutions of Henan Province, China [17A310023]
- National Natural Science Foundation of China [81702891]
- Taihang Young Scholar Foundation of Xinxiang Medical University
- Doctoral Scientific Research Foundation of Xinxiang Medical University [505079]
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Colorectal cancer (CRC) is the third leading cause of cancer-associated mortality, and is a major health problem. Collagen type I 1 (COL1A1) is a major component of collagen type I. Recently, it was reported to be overexpressed in a variety of tumor tissues and cells. However, the function of COL1A1 in CRC remains unclear. Herein, the present study demonstrated that COL1A1 was upregulated in CRC tissues and the paired lymph node tissues. Transwell assays showed that COL1A1 promoted CRC cell migration in vitro. Moreover, it was revealed that COL1A1 levels were correlated with those of WNT/planar cell polarity (PCP) signaling pathway genes; inhibition of COL1A1 decreased the expression levels of Ras-related C3 botulinum toxin substrate 1-GTP, phosphorylated-c-Jun N-terminal kinase, and RhoA-GTP, all of which are key genes in the WNT/PCP signaling pathway. These results may indicate the mechanisms underlying the oncogenic role of COL1A1 in CRC. In summary, the present data indicated that COL1A1 may serve as an oncoprotein, and that it may be used as a potential therapeutic target in CRC.
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