Journal
MOLECULAR MEDICINE REPORTS
Volume 17, Issue 5, Pages 6935-6941Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2018.8739
Keywords
CC chemokines; CXC chemokines; thymic stromal lymphopoietin; airway epithelial cell; asthma
Categories
Funding
- National Natural Science Foundation of China [81270065, 81370116, 81570026, 81670002, 3167188]
- Hunan Natural Science Foundation [2013JJ4030, 2015JJ3170, 2015JJ2147, 2017JJ2402]
- National Basic Research Program of China (973 Program) [2012CB518104]
- Open Foundation of Hunan College Innovation Program [16K097, 14K109]
- Youth Support Program of China Science Communication
- Fundamental Research Funds for the Central Universities of Central South University [45 (2015)]
Ask authors/readers for more resources
As the first barrier to the outside environment, airway epithelial cells serve a central role in the initiation and development of airway inflammation. Chemokines are the most direct and immediate cell factors for the recruitment and migration of inflammatory cells. The present review focused on the role of epithelial chemokines in the pathogenesis of airway inflammation in asthma. In addition to traditional CC family chemokines and CXC family chemokines, airway epithelial cells also express other chemokines, including thymic stromal lymphopoietin and interleukin-33. By expressing and secreting chemokines, airway epithelial cells serve a key role in orchestrating airway inflammation in asthma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available