Journal
MOLECULAR MEDICINE REPORTS
Volume 18, Issue 1, Pages 455-460Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2018.8949
Keywords
sevoflurane; breast cancer cell; proliferation; cell cycle; miR-203
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Funding
- Science and Technology Research Project of Henan Province [142102310459, 162102310228]
- Medical Co construction Project of the Department of Health and Henan Province [201701035]
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Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation. The present study indicated the function of the sevoflurane/miR-203 signaling pathway on regulating breast cancer cell proliferation. These results provide mechanistic insight into how the sevofluranelmiR-203 signaling pathway supresses proliferation of breast cancer cells, suggesting the sevoflurane/miR-203 pathway may be a potential target in the treatment of breast cancer.
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