Journal
MOLECULAR IMMUNOLOGY
Volume 113, Issue -, Pages 38-42Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.12.026
Keywords
DRiPs; Immunoribosomes; MHC-I; Antigen presentation; Immunosurveillance
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Funding
- Division of Intramurarl Research, NIAID, Bethesda, MD
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The MHC class I antigen presentation pathway enables T cell immunosurveillance of cancer cells, viruses and other intracellular pathogens. Rapidly degraded newly synthesized proteins (DRiPs) are a major source of self-, and particularly, viral antigenic peptides. A number of findings support the idea that a substantial fraction of antigenic peptides are synthesized by immunoribosomes, a subset of translating ribosomes that generate class I peptides with enhanced efficiency. Here, we review the evidence for the immunoribosome hypothesis.
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