Journal
CHINESE JOURNAL OF NATURAL MEDICINES
Volume 11, Issue 6, Pages 577-587Publisher
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.3724/SP.J.1009.2013.00577
Keywords
Radix Angelica Sinensis; Chemical constituents; Pharmacological effect; Interactions; Clinical applications; Toxicity
Funding
- National Key Subject of Drug Innovation [2013ZX09402-202]
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The roots of Angelica sinensis (RAS), are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women's diseases. It has also been widely marketed as health food for women's care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregulatory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabiolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.
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