Journal
MOLECULAR DIVERSITY
Volume 22, Issue 2, Pages 323-333Publisher
SPRINGER
DOI: 10.1007/s11030-017-9805-0
Keywords
Benzo[1,3]diazepine; Diaryl[d, f][1,3]diazepine; Structure-activity relationship; Anti-cancer activity
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Funding
- Tang Aoqing Professorship Research Grant from Jilin University
- National Natural Science Foundation of China [811722914, 81072526, 81071743]
- Jilin Province Talent Development Program
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We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 concentration, cell arrest was observed in the G2/M phase. [GRAPHICS] .
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