MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis

Mitochondrial protein import stress compromises functioning of the organelles, due to inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new monitoring pathway in budding yeast, which restores mitochondrial function following the clearing of accumulated unfolded pre-transported mitochondrial proteins, by devising a molecular strategy of overexpressing bi-partite-containing mitochondrial proteins.