Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 35, Issue 6, Pages 1332-1337Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msy083
Keywords
mobile genetic elements; selfish DNA; molecular parasites
Funding
- US National Institutes of Health [R01GM111917]
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Among the multitude of papers published yearly in scientific journals, precious few publications may be worth looking back in half a century to appreciate the significance of the discoveries that would later become common knowledge and get a chance to shape a field or several adjacent fields. Here, Kimura's fundamental concept of neutral mutation-random drift, which was published 50years ago, is re-examined in light of its pervasive influence on comparative genomics and, more specifically, on the contribution of transposable elements to eukaryotic genome evolution.
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