Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 35, Issue 6, Pages 1355-1358Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msy089
Keywords
neutral evolution; selective evolution; HIV
Funding
- National Institutes of Health [R01AI087520]
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HIV is one of the fastest evolving organisms known. It evolves about 1 million times faster than its host, humans. Because HIV establishes chronic infections, with continuous evolution, its divergence within a single infected human surpasses the divergence of the entire humanoid history. Yet, it is still the same virus, infecting the same cell types and using the same replication machinery year after year. Hence, one would think that most mutations that HIV accumulates are neutral. But the picture is more complicated than that. HIV evolution is also a clear example of strong positive selection, that is, mutants have a survival advantage. How do these facts come together?
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