Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 64, Issue -, Pages 161-168Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2018.03.003
Keywords
Polyunsaturated fatty acids; Isoprostanes; Neuroprostanes; Oxidative stress; Non-enzymatic metabolites; Arrhythmias
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omega 3 Polyunsaturated fatty acids (omega 3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely omega 3 PUFAs per se that are biologically active but the nonenzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes and neuroprostanes. Recent question arises how these molecules take part in physiological homeostasis, show biological bioactivities and anti-inflammatory properties. Furthermore, they are involved in the circulations of childbirth, by inducing the closure of the ductus arteriosus. In addition, oxidative stress which can be beneficial for the heart in given environmental conditions such as the presence of omega 3 PUFAs on the site of the stress and the signaling pathways involved are also explained in this review.
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