Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 60, Issue -, Pages 69-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2017.12.002
Keywords
Extracellular vesicles; Trophoblast; Preeclampsia; Pregnancy; Human
Funding
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [3160194, 1150377]
- Comision Nacional de Investigacion y Desarrollo (CONICYT)-Chile
- Faculty of Medicine, PUC-PhD fellowships, Chile
Ask authors/readers for more resources
Intercellular communication is a critical process in biological mechanisms. During pregnancy foetopla-cental tissues release a heterogeneous group of extracellular vesicles (EVs) that include exosomes, microvesicles, apoptotic bodies, and syncytial nuclear aggregates. These vesicles contain a complex cargo (proteins, DNA, mRNA transcripts, microRNAs, noncoding RNA, lipids, and other molecules) that actively participate in the maternal-foetal communication by modulating different processes during gestation for a successful foetal development. Each stage of human gestation is marked by events such as immuno-modulation, proliferation, invasion, migration, and differentiation, among others, requiring EVs-mediated signalling to be nearby or distant target cells. Furthermore, EVs also associate with pregnancy pathologies such as preeclampsia and intrauterine growth restriction. This review addresses the role of EVs in human foetomaternal communication in normal pregnancy and preeclampsia. (c) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available