Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 88, Issue -, Pages 1-6Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2017.12.003
Keywords
Alzheimer's disease; trans epsilon-viniferin; Amyloid fibrils; Inflammation; Multi-target molecule
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Funding
- French Ministry of Education and Research and Technology [EA3808]
- country Poitou Charentes (VinOx project)
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Alzheimer's disease (AD) is marked by several cellular and molecular damage. Therefore, the therapeutic interest of multi-target molecules is increasingly justified. Polyphenols presenting multiple pharmacological effects would be more efficient. In this study, beneficial effects of trans epsilon-viniferin, a natural polyphenol were thus evaluated. This study reported that this stilbenoid (1) induced the disaggregation of amyloid beta (A beta) peptide and (2) rescued inflammation in murine primary neuronal cultures. These both effects are higher than those of resveratrol, and so, trans epsilon-viniferin could be a good therapeutic multi-target candidate.
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