Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 470, Issue -, Pages 219-227Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.11.002
Keywords
Ageing; Granulosa cell; Receptor expression; Fertility; Apoptosis
Categories
Funding
- Australian Postgraduate Award
- Curtin University Postgraduate Scholarship
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The poor oocyte quality in older women has previously been linked to the depletion of the ovarian reserve of primordial follicles and an increase in granulosal apoptosis. Granulosa cells were collected from 198 follicles and individually analysed by flow cytometry. In the young IVF patients, the level of apoptosis was inversely proportional to the expression of bone morphogenetic protein (BMPRIB) and follicle stimulating hormone (FSH) receptors. Conversely, in the older patients this relationship became dysregulated. In the older patients, at the time of preovulatory maturation, the reduced apoptosis reflects the poor mitogenic growth turnover rate of healthy follicles rather than the death rate in an atretic follicle. Restoring an optimum receptor density and down-regulation of receptors may improve oocyte quality and the pregnancy rate in older women. (C) 2017 Elsevier B.V. All rights reserved.
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