Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 465, Issue C, Pages 48-60Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.09.022
Keywords
Endometrium; Androgen receptor (AR); Decidualisation; Proliferation; Testosterone (T); Dihydrotestosterone (DHT); AKR1C3; SRD5A1; Scarless healing; Endometriosis; Cancer
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Funding
- Medical Research Council [G1100356/1, MR/N024524/1, MR/1300256X/1]
- Medical Research Council [MR/P00265X/1, MR/N024524/1] Funding Source: researchfish
- MRC [MR/N024524/1, MR/P00265X/1] Funding Source: UKRI
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Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome, endometriosis and endometrial cancer. The endometrium is an androgen target tissue and the impact of AR-mediated effects has been studied using human endometrial tissue samples and rodent models. In this review we highlight recent evidence that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. The impact of androgens on endometrial cell proliferation, in repair of the endometrial wound at the time of menstruation and in endometrial disorders is discussed. Future directions for research focused on AR function as a therapeutic target are considered. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.
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