Journal
MODERN RHEUMATOLOGY
Volume 28, Issue 5, Pages 838-844Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14397595.2017.1416739
Keywords
Biomarker; IgG4-related disease; soluble IL-2 receptor
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Funding
- Practical Research Project for Rare/Intractable Diseases from Japan Agency for Medical Research and development, AMED [16ek0109051h0003]
- Research Program of Intractable Disease
- Ministry of Health, Labor, and Welfare of Japan [H26-Nanchi-Ippan-050]
- Japan Society for the Promotion of Science [26461187]
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Objectives: Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to elucidate the clinical significance of blood markers, including sIL-2R, in patients with IgG4-RD.Methods: We enrolled 59 patients with IgG4-RD and investigated the association between blood markers (white blood cells, C-reactive protein, sIL-2R, IgG, IgG4, IgE, total hemolytic complement), and clinical indices.Results: At baseline, serum sIL-2R (Rs=0.532, p<.001) and IgG4 (Rs=0.545, p<.001) levels showed significant correlation to the number of organs involved. During follow-up period (median, 70 months; range, 7-195 months), 40 patients were treated with corticosteroids. Receiver operating characteristic (ROC) analysis showed that baseline sIL-2R levels most accurately predicted patients requiring glucocorticoid treatment (area under the ROC curve, 0.807). Among the 46 patients who improved, sIL-2R and IgG4 levels decreased in 42 and 41 patients, respectively. Among them, serum sIL-2R levels decreased to a normal range in 42 patients (91%), whereas IgG4 levels normalized in 19 (41%).Conclusion: The serum sIL-2R level is a potential biomarker for IgG4-RD that may reflect the number of involved organs and may predict patients requiring glucocorticoid treatment.
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