Journal
HEPATOLOGY
Volume 62, Issue 4, Pages 1304-1312Publisher
WILEY-BLACKWELL
DOI: 10.1002/hep.27867
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Funding
- NCI NIH HHS [R01 CA190176, K08 CA151414, R01 CA152470] Funding Source: Medline
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Hepatocellular carcinoma (HCC) is highly associated with inflammation. Myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells, are abundant in the HCC microenvironment and are often associated with poor prognosis. Myeloid cells in HCC play a vital role in supporting tumor initiation, progression, angiogenesis, metastasis, and therapeutic resistance. Here, we summarize our current knowledge about myeloid cells in HCC and focus on their immune-suppressive activities and tumor-promoting functions, as well as the relevance to potential new therapies in HCC. (Hepatology 2015;62:1304-1312)
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