Journal
MITOCHONDRION
Volume 41, Issue -, Pages 45-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.11.002
Keywords
Mitochondria; Cellular metabolism; Immunity; Macrophages; T cells; PRRs
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Funding
- SNSF [31003A_163204]
- ISREC [26075483]
- Swiss Cancer Foundation [KFS-3949-08-2016]
- Harry J. Lloyd Charitable Foundation
- Melanoma Research Alliance Young Investigator Award
- Cancer Research Institute-CLIP
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Orchestrating biological activities of immune cells through metabolic reprogramming reveals a new approach to harnessing immune responses. Increasing evidence reveals that the mitochondrion is a central regulator for modulating metabolic reprogramming and controlling immune cell activation and functions. In addition to supporting bioenergetic demands, the mitochondrion serves as a signaling platform through the generation of reactive oxygen species and metabolites of the tricarboxylic acid cycle to modulate signaling cascades controlling immune cell activation and immune responses. Herein, we discuss the mechanisms through which the mitochondrion acts as a master regulator to fine-tune immune responses elicited by macrophages and T cells.
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