Journal
MITOCHONDRION
Volume 46, Issue -, Pages 103-115Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2018.03.002
Keywords
Mitochondria; Immune response; Alloreactivity; Allogeneic; Syngeneic allogeneic; Skin allograft
Categories
Funding
- NIH [5T32HL007734]
- Richard A. and Susan F. Smith President's Innovation Award
- Michael B. Klein and Family
- Sidman Family Foundation
- Michael B. Rukin Charitable Foundation
- Kenneth C. Griffin Charitable Research Fund
- Boston Investment Council
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Previously, we have demonstrated that the transplantation of autologous mitochondria is cardioprotective. No immune or autoimmune response was detectable following the single injection of autologous mitochondria. To expand the therapeutic potential and safety of mitochondrial transplantation, we now investigate the immune response to single and serial injections of syngeneic and allogeneic mitochondria delivered by intraperitoneal injection. Our results demonstrate that there is no direct or indirect, acute or chronic alloreactivity, allorecognition or damage-associated molecular pattern molecules (DAMPs) reaction to single or serial injections of either syngeneic or allogeneic mitochondria.
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