Journal
MITOCHONDRION
Volume 45, Issue -, Pages 7-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2018.01.009
Keywords
Cyanide-resistant respiration; Rotenone-insensitive NADH dehydrogenase; Comparative bioenergetics; Gene therapy; Mitochondrial disease; Hypoxia
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Funding
- Ministry of Education and Science of Ukraine [0115U002304]
- Natural Sciences and Engineering Research Council in Canada [402551-11]
- Canada Foundation for Innovation [32728]
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The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks. Two of these enzymes, the alternative NADH dehydrogenase and the alternative oxidase, were of interest to a limited circle of researchers until they were envisioned as gene therapy tools for mitochondrial disease treatment. Recently, these enzymes were discovered in several animals. Here, we analyse the functioning of alternative NADH dehydrogenases and oxidases in different organisms. We propose that both enzymes ensure bioenergetic and metabolic flexibility during environmental transitions or other conditions which may compromise the operation of the canonical respiratory system.
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