Journal
MITOCHONDRION
Volume 40, Issue -, Pages 1-12Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.08.015
Keywords
NAFLD; Steatosis; Mitochondria; Western diet
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [RU742/6-1]
- Faculty of Medicine of the University Munich (LMU) [905]
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Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
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