Journal
MINI-REVIEWS IN ORGANIC CHEMISTRY
Volume 15, Issue 6, Pages 498-507Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570193X15666180220141342
Keywords
Alkaloids; carbazole; resistance; SAR; tuberculosis; antitubercular drugs
Categories
Funding
- Ministry of Human Resource and Development (MHRD), Government of India
- Department of Biotechnology (DBT), New Delhi, India [BT/PR9624/MED/30/1253/2013]
Ask authors/readers for more resources
The control of Tuberculosis (TB) is becoming more challenging due to drug resistance. Therefore, there is a dire need for newer drugs to tackle the nuances of resistant strains. Many molecular scaffolds are in the pipeline against TB. Among them, carbazole has a distinct advantage over other scaffolds because of its various sources i.e. medicinal plants, coal tar, and synthesis, besides the excellent antitubercular efficacy. This review provides an overview of carbazole alkaloids and their synthetic derivatives reported against Mycobacterium tuberculosis H37Rv (Mtb). The structure-activity relationship is also established to understand the molecular requirements for design and development of more potent antitubercular drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available