Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 18, Issue 3, Pages 216-233Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666170127121215
Keywords
Analgesic; anti-inflammatory; scaffold; COX; 1,3,4-Oxadiazole; NSAIDs
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1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4-oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.
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