Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 19, Issue 5, Pages 437-447Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557518666180329122317
Keywords
1,3,4-thiadiazoles; fused imidazoles; heterocyclic amines; microwave irradiation; anti-inflammatory; analgesic and anti-ulcer agents
Categories
Ask authors/readers for more resources
Background: A novel series of fused imidazole was prepared from the reaction of 2-bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation, The structures of all the novel products were elucidated based on the elemental analysis and spectral data. Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti-ulcer agents. Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available