Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 18, Issue 5, Pages 392-413Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666171101111134
Keywords
Binding mode; biological activities; derivates; quinoxaline; quinoxalinone skeleton; SAR analysis
Categories
Funding
- Key Research and development project of Shandong Province [2016GSF201175]
- Natural Science Foundation of Shandong Province [ZR2013HM101]
- Shandong Innovation and Transformation of Achievements Grant [2014ZZCX02601]
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001]
- Natural Science Foundation of China [81471974]
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Among the family of nitrogen-containing heterocycles, quinoxalinone (or quinoxalin-2-one) core, characterized by pyrazin-2(1H)-one fused to benzene ring at two adjacent carbon atoms, has been frequently found in a variety of pharmacologically active compounds with biological or pharmaceutical applications. It was gratifying that a larger part of these bioactive quinoxalinone-based derivatives has entered various clinical trials, which in turn hastens the synthetic versatility and also initiates various derivatization of quinoxalinone scaffold. In this review, we highlighted the newly emerged quinoxalinone-based derivatives or analogues, with the emphasis of their biological applications and structure-activity analysis covering literatures in recent years.
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