Journal
MICROCHIMICA ACTA
Volume 185, Issue 3, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-018-2705-x
Keywords
Cardiac biomarker; Plasmonic hotspots; SERS aptasensor; SELEX; Nanohybrid
Categories
Funding
- CSIR-JRF
- INST-PhD
- INST-PDF
- DST, Govt. of India
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A nanohybrid mediated SERS substrate was prepared by in-situ synthesis and assembly of gold nanoparticles (AuNPs) on exfoliated nanosheets of tungsten disulfide (WS2) to form plasmonic hotspots. The nanohybrid surface was functionalized with specific aptamers which imparted high selectivity for the cardiac marker myoglobin (Mb). The fabricated aptasensor was read by SERS using a 532 nm laser and demonstrated significant signal enhancement, and this allowed Mb to be determined in the 10 f.mL(-1) to 0.1 mu g mL(-1) concentration range. The study presents an approach to synergistically exploit the unique chemical and electromagnetic properties of both WS2 and AuNPs for many-fold enhancement of SERS signals.
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